Cigarette Smoking Augments Sympathetic Nerve Activity in Patients With Coronary Heart Disease
スポンサーリンク
概要
- 論文の詳細を見る
It has been shown that cigarette smoking increases blood pressure (BP) and heart rate (HR), and decreases muscle sympathetic nerve activity (MSNA) in healthy young smokers. The decrease in MSNA might be secondary to baroreflex responses to the pressor effect. We tested the hypothesis that cigarette smoking increases MSNA in smokers with impaired baroreflex function. The effects of cigarette smoking on BP, HR, forearm blood flow (FBF), forearm vascular resistance (FVR), and MSNA were examined in 14 patients with stable effort angina (59 ± 3 years, group CAD) and 10 healthy smokers (23 ± 1 years, group C). In group CAD, the arterial baroreflex sensitivity (BRS) was significantly lower than in group C (4.7 ± 0.8 versus 15.1 ± 2.2 msec/mmHg, P < 0.01). In both groups, cigarette smoking increased the plasma concentration of nicotine, systolic and diastolic BP, HR, and FVR significantly (P < 0.01), but decreased FBF significantly (P < 0.01). After smoking, MSNA was decreased significantly in group C (from 35.2 ± 3.5 to 23.5 ± 3.2 bursts/100 beats, P < 0.01), but increased significantly in group CAD (from 48.8 ± 5.4 to 57.3 ± 5.5 bursts/100 beats, P < 0.01). There was significant correlation between BRS and changes in MSNA (r = -0.62, P < 0.01). Cigarette smoking increased MSNA in smokers with impaired baroreflex function. This demonstrates that cigarette smoking stimulates sympathetic nerve activity by both a direct peripheral effect and a centrally mediated effect.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
-
Takata Shigeo
Department Of Cardiology Kanazawa University Graduate School Of Medicine
-
Shinozaki Norihiko
Department of Cardiology, Kokura Memorial Hospital
-
Shinozaki Norihiko
長野県厚生農業協同組合連合会篠ノ井総合病院 循環器科
-
Yuasa Toyoshi
Department of Cardiology, Matto-Ishikawa-chuo Hospital
-
Takata Shigeo
Department Of Cardiology Kanazawa City Hospital
-
Shinozaki Norihiko
Department Of Cardiac Surgery And Cardiology Cardiovascular Center Shinonoi General Hospital
-
Takata Shigeo
Department of Cardiology, Kanazawa Municipal Hospital
関連論文
- Initial and Follow-up Results of the Biodiv Ysio Phosphorylcholine Coated Stent for Treatment of Coronary Artery Disease
- FRS-165 Initial and follow up results of BiodivYsio PC coated stent(Coronary Heart Disease : Basic Science (IHD) : FRS20)(Featured Research Session (English))
- Cigarette Smoking Augments Sympathetic Nerve Activity in Patients With Coronary Heart Disease
- Selective Intracoronary Administration of Nitroprusside Before Balloon Dilatation Prevents Slow Reflow During Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction
- Biochemical analysis of airway aspirates of newborns
- PJ-672 G_ and G_q Coordinately Mediate S1P_2-induced Inhibition of Rac and Migration in Vascular Smooth Muscle in Rho-dependent Manner(PJ113,Atherosclerosis, Basic 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-373 Sphingosine-1-Phosphate Inhibits the Formation of Tube-Like Structures via Its Receptor EdgS in Vascular Endothelial Cells(Angiogenesis 3 (IHD) : PJ62)(Poster Session (Japanese))
- PE-348 G_q- and G_-coupled activation of Rho mediates inhibitory regulation of cellular Rac and chemotaxis in VSMCs(Molecular Biology, Vascular 3 (H) : PE59)(Poster Session (English))
- OE-012 Knockdown of Edg1 Gene Expression by RNA Interference Abolishes Sphingosine-1-Phosphate-Induced Platelet-Derived Growth Factor-B Chain Expression in Vascular Smooth Muscle Cells(Vasoactive Compound/Growth Factor/Cytokine 1 (H) : OE2)(Oral Presentat
- Sphingosine-1-Phosphate Stimulates Gene Expression of the Transcription Factor KLF5/BTEB2, Which Plays a Critical Role in PDGF-B Gene Expression, in VSMCs
- The Small GTPase Rho Mediates Sphingosine-1-Phosphate Induced Inhibition of Chemotaxis Toward PDGF through Inhibiting Rac in Vascular Smooth Muscle Cells
- Roles for the small G proteins and downstream protein kinases in sphingosine-1-phosphate(S1P)-induced PDGF-B chain gene expression in VSMCs
- Current Status of Anticoagulation Therapy for Elderly Atrial Fibrillation Patients in Japan : From Hokuriku Atrial Fibrillation Trial
- PJ-232 Alterd Interaction between Plasminogen Activator Inhibitor Type 1 Activity and Sympathetic Nerve Activity with Aging(Atherosclerosis,clinical(10)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-146 Current Status of Anticoagulation Therapy for Elderly Patients, from Hokuriku Atrial Fibrillation Trial(Arrhythmia, therapy(12)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-124 Antioxidative Effect Provided with Statin Is Independent from LDL Lowering Mechanisms in the Clinical Course of Acute Coronary Syndrome(Acute coronary syndrome, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of t
- PE-033 Altered Firing Pattern of Single-unit Sympathetic Vasoconstrictor Fibers during Exercise in Chronic Heart Failure(Autonomic nervous system(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-102 Sympathetic Augmentation was Induced by Strict Rate Control in AF Patient(Autonomic nervous system(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Altered Interaction Between Plasminogen Activator Inhibitor Type 1 Activity and Sympathetic Nerve Activity With Aging
- PJ-467 Interaction of Low Dose of Endotheline Blockade and Beta-adrenergic Receptor Antagonist Improved Coronary Flow Reserve after Ischemia Reperfusion Injury(Coronary circulation, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circ
- PJ-263 Additional Administration of Angiotensin Receptor Blockade with Aldosteron Antagonist Improved Oxidative Stress after Acute Coronary Syndrome in Human(Myocardial ischemia/reperfusion, basic/clinical-5, The 71st Annual Scientific Meeting of the Japa
- PJ-260 The Reduction of Cellular ER Stress Regarding with Chemical Chaperon Improves Myocardial Ischemia Reperfusion Injury in Mice(Myocardial ischemia/reperfusion, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-077 Atrial Fibrillation Itself Augments Single-unit Muscle Sympahtetic Nerve Activity in Congestive Heart Failure(Autonomic nervous system-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-203 Effect of Elevated Arterial Pressure on Vascular Functional and Structural Atherosclerosis in the Hypertensive Patients(Atherosclerosis, clinical-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-137 Azelnidipine Inhibits Single-unit Muscle Sympathetic Nerve Activity in Healthy Humans(Autonomic nervous system-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-183 Antiarrhythmic and Anticoagulation Therapy for Atrial Fibrillation in Japan : Hokuriku Atrial Fibrillation Trial(Arrhythmia, therapy-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-227 Diabetes Mellitus Impairs Endocardial Function in Rat Atria(Thromboembolism/Antithrombotic therapy/Thrombolysis-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-576 Interaction of Endotheline Blockade and Beta-adrenergic Receptor Antagonist Improved Myocardial Apoptosis after Ischemia Reperfusion Injury in the Rat Heart(Acute coronary syndrome, basic/clinical-8 (IHD) PJ97,Poster Session (Japanese),The 70th Ann
- PJ-492 Low Frequency Components of Peripheral Vascular Resistance Variability Reflects Sympathetic Nerve Activity in Congestive Heart Failure(Autonomic nervous system-5 (H) PJ83,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of t
- PE-029 Responsiveness to Left Atrial Volume Reduction after Left Atrial Catheter Ablation for Paroxysmal Atrial Fibrillation : Evaluation by 16-MDCT(Arrhythmia, diagnosis/pathophysiology/EPS-7 (A) PE5,Poster Session (English),The 70th Anniversary Annual S
- 0646 EFFECTS OF ENDOSCOPIC TRANSTHORACIC SYMPATHICOTOMY ON CIRCADIAN VARIATION OF CARDIAC AUTONOMIC ACTIVITY
- Electrophysiolosical changes in crista terminalis following administration of class IC anti-arrhythmic drug : An analysis using CARTO system
- Low-Dose Atropine Attenuates Muscle Sympathetic Nerve Activity in Healthy Humans
- Bilateral Coronary Artery Fistulas With Multiple Sites of Drainage
- Relative sympathetic burst area distribution; A new and quantitative indicator of sympathoexcitation in humans
- Tissue Doppler Analysis of Atrial Electromechanical Coupling in Paroxysmal Atrial Fibrillation
- Ultrasonic Tissue Characterization in Acute Myocarditis : A Case Report
- ASYMPTOMATIC MYOCARDIAL Ischemia IN DIABETIC PATIENTS : Ischemic Heart Disease : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Prevalence of Migraine and Raynaud's Phenomenon in Japanese Patients With Vasospastic Angina
- A New Noninvasive and Ambulatory Monitoring Device Using Pillow's with Sleep Apnea Syndrome (Preventive Medicine/Epidemiology/Education/Health Policy 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Quantiative Analysis of Oxidative Stress Directly Reflect the Clinical Course of Acute Coronary Syndrome(Acute Coronary Syndrome, Basic/Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Attenuation of Carotid Arterial Distensibility Contributes to an Inhibition of Arterial Baroreflex During Handgrip Exercise(Echo/Doppler 10 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Interaction of Endotheline Blockade and Aldosterone Blockade Improved Myocardial Dysfunction After Ischemia Reperfusion Injury in the Rat Heart(Acute Myocardial Infarction, Basic 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Soci
- Effects of Physiological Stresses on Low Frequency Components of Peripheral Vascular Resistance Variability in Human(Autonomic Nervous System 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-019 A New System for the Continuous Automated Measurement of the Carotid Arterial Wall Dynamics(Echo/Doppler 2 (I) : PJ4)(Poster Session (Japanese))
- PE-140 Interaction of endotheline and aldosterone impaired exercise induced coronary response during exercise in heart failure(Coronary Circulation, Basic/Clinical 1 (IHD) : PE24)(Poster Session (English))
- PE-093 Influences of Pressor Stimuli on the Distensibility of Carotid Artery in Humans(Autonomic Nervous System 1 (H) : PE16)(Poster Session (English))
- PE-003 Rho-kinase Inhibitor Fasudil Prevents Atrial Electrical Remodeling in Atrial Fibrillation(Arrhythmia, Basic 2 (A) : PE1)(Poster Session (English))
- OJ-200 Effect of Aging on Low Frequency Components of Peripheral Vascular Resistance Variability in Human(Autonomic Nervous System 2 (H) : OJ23)(Oral Presentation (Japanese))
- Transcutaneous Near-Infrared Ray Irradiation Accelerates Reendothelialization and Attenuates Neointima Formation in a Rat Balloon-Injured Model
- Effects of transcutaneous near-infrared ray irradiation on intimal hyperplasia in a rat balloon injury model
- Non-invasive and ambulatory monitoring of beat-to-beat cardiovascular hemodynamic variables in patients with hemodiatysis
- OJ-094 Selective Intracoronary Administration of Nitroprusside before Balloon Dilatation Prevents Slow Flow during Primary Angioplasty in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-3 (IHD) OJ16,Or
- FRS-075 AGEs-RAGE System Mediates Atrial Structural Remodeling via Upregulating Connective Tissue Growth Factor in Diabetic Rat(Arrhythmia (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Aging Does Not Influence Sympathetic Neurotransmission Property to Arterial Pressure in Humans
- Impaired Sympathetic Nerve Transmission in Heart Failure : Evaluation Using Akaike's Relative Power Contribution Analysis
- P Wave Morphological Analysis during Pulmonary Vein Pacing : Spatial Characteristics of 3-Dimensional P Wave Loop
- New Quantitative and Qualitative Indicators of Sympathoexcitationin Humans : Evaluation of Reproducibility
- Transcutaneous near-infrared ray irradiation prevents restenosis after transluminal angioplasty in patients with hemodialysis access-shunt occulusion
- Recordings of Muscle Sympathetic Vasoconstrictor Fiber Activity in Humans
- Low frequency component of peripheral vascular resistance variability reflects sympathetic outflow
- Enhanced contribution of NO to exercise-induced coronary responses after α-adrenergic receptor blockade
- Effects of Linear Polarized Near-Infrared Ray Irradiation Near the Left Stellate Ganglion on Electrocardiogram in Drug-induced QT Prolongation
- PE-208 Development of Decompensated Cardiac Hypertrophy in Transgenic Mice That Overexpress S1P1 under the Control of Alpha Smooth Muscle Actin Promoter(Cardiac hypertrophy, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation
- P648 Predominance of Arterial Baroreflex Over Cardiopulmonary Baroreflex During Ventricular Tachycardia
- An Excitation Control Method Peculiar to the 2-Axis Synchronous Machine
- PE-002 Additional Administration of T-type Ca Antagonist Significantly Improved Oxidative Stress After Acute Coronary Syndrome in Human(Acute coronary syndrome, basic/clinical-4 (IHD) PE1,Poster Session (English),The 70th Anniversary Annual Scientific Mee
- OJ-328 Multiple within Burst Firing of Single Vasoconstrictor Neurons is an Important Role during Excessive Sympathoexcitation in Humans(Autonomic nervous system-2 (H) OJ55,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the
- OE-122 Different Sympathoexcitation Pattern of Single Vasoconstrictor Fiber in Congestive Heart Failure(Autonomic nervous system-1 (H) OE21,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- P561 M-MODE COLOR TISSUE DOPPLER IMAGING OF LEFT VENTRICULAR FUSION BEATS BY ATRIO-MITRAL ANNULAR SEQUENTIAL PACING
- PJ-235 In-hospital and long-term clinical outcome of abrupt closure after percutaneous coronary intervention in the patients with acute myocardial infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 8 (IHD) : PJ40)(Poster Session (Japan
- PJ-146 NO Fails to Limit Constriction of Large Coronary Arteries during Exercise after β-Adrenergic Receptor Blockade(Endothelium/NO 2 (H) : PJ25)(Poster Session (Japanese))
- Coronary Artery Bypass Grafting for Acute Myocardial Infarction in Stent ERA
- Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice
- Contemporary Outcomes After Endovascular Treatment for Aorto-Iliac Artery Disease
- Effect of Body Position on Skin Perfusion Pressure in Patients With Severe Peripheral Arterial Disease
- Clinical Impact of Bisoprolol Versus Carvedilol in Patients Undergoing Femoropopliteal Stenting
- Diagnostic Accuracy of Global Registry of Acute Coronary Events (GRACE) Risk Score in ST-Elevation Myocardial Infarction for In-Hospital and 360-Day Mortality in Japanese Patients