Effect of Early Versus Late In-Hospital Initiation of Statin Therapy on the Clinical Outcomes of Patients With Acute Coronary Syndrome

スポンサーリンク

概要

• 論文の詳細を見る

• Statins provide effective secondary prevention of cardiovascular events after acute coronary syndrome (ACS). Current guidelines recommend that statins be initiated in ACS patients before hospital discharge. In this retrospective study, we investigated the influence of early compared with late in-hospital initiation of statin therapy on the clinical outcomes of ACS patients. Two hundred and ten ACS patients who had no history of statin treatment before hospitalization were enrolled. The patients were divided into early (statin treatment initiated ≤ 2 days after admission) and late (statin treatment initiated > 2 days after admission and before discharge) statin groups. We examined the association between early statin use and clinical outcomes in these patients using Cox proportional hazards models. Four months after discharge, event-free survival was 85% in the early statin group and 79% in the late statin group. In multivariate analyses, Killip IV classification and abnormal renal function were independent predictors of the composite endpoint of cardiovascular death, recurrent myocardial infarction, angina requiring rehospitalization, revascularization, and stroke. Early statin treatment had no significant influence (hazard ratio: 1.11; 95% confidence interval: 0.54 to 2.25; P = 0.78) on the composite endpoint 4 months after discharge. At 12 months after discharge, early statin treatment still had no significant influence on the composite endpoint (hazard ratio: 1.53; 95% confidence interval: 0.83 to 2.81; P = 0.17). We concluded that ensuring all eligible ACS patients begin statin therapy during their hospital stay is more important than emphasizing immediate statin use after admission.

• International Heart Journal刊行会の論文

著者

• Li Yi-heng

  Department Of Internal Medicine National Cheng Kung Univ. Hospital

• Yang Yea-huei

  Institute of Clinical Pharmacy, College of Medicine, National Cheng Kung University

• Yang Yea-huei

  Institute Of Biopharmaceutical Science College Of Medicine National Cheng Kung University

• Wu Hui-Ling

  Institute of Clinical Pharmacy, College of Medicine, National Cheng Kung University

• Tsai Hui-Shan

  Department of Pharmacy, College of Medicine, National Cheng Kung University

• Chao Ting-Hsing

  Department of Internal Medicine, College of Medicine, National Cheng Kung University

• Li Yi-Heng

  Department of Internal Medicine, College of Medicine, National Cheng Kung University

関連論文

• PE-552 The Clinical Significance of Drug-Drug Interactions from Different Prescriptions in Hypertensive Patients(Preventive medicine/Epidemiology/Education-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• IS041 Functional Mutation in the Promoter Region of Thrombomodulin Gene in Relation to Carotid Atherosclerosis
• Epidemiology and Predictors of Short-Term Mortality in Symptomatic Venous Thromboembolism : A Nationwide Population-Based Study
• A Novel Inhibitory Effect of Antrodia Camphorata Extract on Vascular Smooth Muscle Cell Migration and Neointima Formation in Mice
• Effect of Early Versus Late In-Hospital Initiation of Statin Therapy on the Clinical Outcomes of Patients With Acute Coronary Syndrome

スポンサーリンク