Inverse Relationship Between Adiponectin Levels and Subclinical Carotid Atherosclerosis in Patients Undergoing Coronary Artery Bypass Grafting

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概要

• 論文の詳細を見る

• The purpose of this study was to examine the relation between adiponectin levels and subclinical carotid atherosclerosis in patients undergoing coronary artery bypass grafting (CABG). Serum concentrations of adiponectin and carotid intima/media thickness (IMT) were measured in 84 consecutive patients who underwent CABG. Carotid IMT both at the common carotid artery and carotid bulb level was correlated negatively and significantly (r = -0.581 and r = -0.415, respectively, P < 0.01) with the serum concentrations of adiponectin. Linear regression modeling identified adiponectin as the strongest predictive variable for carotid IMT both at the common carotid artery and carotid bulb level (P < 0.001). Stepwise regression analyses also showed that adiponectin was the strongest independent determinant of the carotid IMT both at the common carotid artery and the carotid bulb level (F = 20.215 and F = 19.565, respectively, P < 0.001). The mean number of diseased coronary arteries, mean number of distal anastomoses, cardiopulmonary bypass time, and aortic cross-clamping time did not significantly correlate with the serum concentrations of adiponectin. The findings indicate the presence of an inverse relationship between serum concentrations of adiponectin and subclinical carotid atherosclerosis in patients undergoing CABG. In these patients, the absence of a significant correlation between severity of coronary atherosclerosis and adiponectin might suggest that adiponectin levels may predict the early stages rather than further progression of atherosclerosis.

• International Heart Journal刊行会の論文

著者

• Kiris Ilker

  Department Of Cardiovascular Surgery Suleyman Demirel University Medical School

• Okutan Huseyin

  Department Of Cardiovascular Surgery Suleyman Demirel University Medical School

• Vural Huseyin

  Departments Of Biochemistry Facylty Of Medicine Harran University Sanliurfa

• Yesildag Ahmet

  Department Of Radiology School Of Medicine Suleyman Demirel University

• KIRIS ILKER

  Department of Cardiovascular Surgery, Suleyman Demirel University Medical School

• Tekin Ilker

  Department of Cardiovascular Surgery, Suleyman Demirel University Medical School

• Oyar Orhan

  Department of Radiology, Suleyman Demirel University Medical School

• Sirin Burcu

  Department of Biochemistry, Suleyman Demirel University Medical School

• Ibrisim Erdogan

  Department of Cardiovascular Surgery, Suleyman Demirel University Medical School

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• Inverse Relationship Between Adiponectin Levels and Subclinical Carotid Atherosclerosis in Patients Undergoing Coronary Artery Bypass Grafting

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