Influence of Primary Coronary Intervention on Myocardial Collagen Metabolism and Left Ventricle Remodeling Predicted by Collagen Metabolism Markers

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概要

• 論文の詳細を見る

• The aims of the present study were to analyze cardiac collagen metabolism changes in vivo during acute and nonacute phases of ST elevation myocardial infarction (STEMI) in patients who were treated with primary coronary intervention (PCI) only, and to determine the predictive significance of collagen I and III synthesis markers (PICP, PIIINP) as well as the collagen I degradation marker (ICTP) on left ventricular function and volume changes after STEMI. Serum levels of the carboxy-terminal propeptide of type I procollagen (PICP) and amino-terminal propeptide of type III procollagen (PIIINP) assessed on the 30th day and the carboxyterminal telopeptide located at the C end of collagen type I (ICTP) assessed on the 7th day after STEMI were significantly higher (P = 0.01, P = 0.019, P = 0.04, respectively) in the PCI unsuccessful group than in the PCI successful group. These findings support the theory that early and successful PCI not only limits the amount of muscle necrosis but also protects cardiac collagen from ischemia-related injury. PICP and PIIINP levels assessed on the fourth day after acute STEMI enables us to predict the development of left ventricular function (EF) and end-diastolic volume changes over the course of 6 months, irrespective of the initial EF or revascularization success.

• International Heart Journal刊行会の論文

著者

• Capek Jan

  Cardiocenter, Department of Cardiology, 3rd Medical School, Charles University and University Hospital, Kralovske Vinohrady

• Jirmár Radovan

  Cardiocenter, Department of Cardiology, 3rd Medical School, Charles University and University Hospital, Kralovske Vinohrady

• Pelouch Václav

  Department of Medical Chemistry and Biochemistry, 2nd Faculty of Medicine, Charles University

• Widimsky Petr

  Cardiocenter, Department of Cardiology, 3rd Medical School, Charles University and University Hospital, Kralovske Vinohrady

• Andel Michal

  2nd Internal Clinic, University Hospital Královské Vinohrady and the 3rd Faculty of Medicine, Charles University

• Prusa Richard

  Department of Clinical Biochemistry and Pathobiochemistry, 2nd Faculty of Medicine, Charles University

• Pechová Martina

  Department of Clinical Biochemistry and Pathobiochemistry, 2nd Faculty of Medicine, Charles University

関連論文

• Inter-hospital Transport for Primary Angioplasty Does Not Compromise Left Ventricular Function : Six-Month Echocardiographic Follow-up of the PRAGUE 1 Study
• Influence of Primary Coronary Intervention on Myocardial Collagen Metabolism and Left Ventricle Remodeling Predicted by Collagen Metabolism Markers
• Next Day Discharge After Successful Primary Angioplasty for Acute ST Elevation Myocardial Infarction An Open Randomized Study "Prague-5":An Open Randomized Study "Prague-5"

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