The Effect of High Temperature on Alveolar Macrophage Counts in Bronchoalveolar Lavage Fluid of F344 Rats

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概要

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• To determine the effects of high temperature on the number of alveolar macrophages (AMs) in bronchoalveolar lavage (BAL) fluid in rats, F344 rats were housed in environment chambers at 23°C, 30°C or 35°C for up to 14 days. The number of AMs in the BAL fluid was significantly decreased in rats housed at 35°C on days 7 and 14, compared to the control group housed at 23°C. The total protein content and lactate dehydrogenase activity did not change at high temperatures in BAL supernatant, indicating that there was no increase in alveolar/capillary barrier permeability or lung cellular injury. The results might suggest that high temperature (35°C) affects the pulmonary defense mechanism.

• 社団法人　日本実験動物学会の論文
• 2002-10-01

著者

• Sato Katsunori

  Division Of Animal Science Faculty Of Agriculture Okayama University

• YAMAMOTO Shiji

  Environmental Health Sciences Division, National Institute for Environmental Studies

• Yamamoto Shiji

  Environmental Health Sciences Division National Institute For Environmental Studies

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• Effects of Dietary Protein Levels on Production and Characteristics of Japanese Quail Eggs
• The Effect of High Temperature on Alveolar Macrophage Counts in Bronchoalveolar Lavage Fluid of F344 Rats

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