Increased Level of Serum Vascular Endothelial Growth Factor by Long-Term Exposure to Hypergravity

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概要

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• We have previously demonstrated that short-term exposure to hypergravity at 2G for 4 h induces expression of cyclooxygenase-2 (COX-2) in the mouse heart. Moreover, expression of vascular endothelial growth factor (VEGF) is also induced in the heart in a COX-2-dependent manner. Here, we demonstrate that long-term exposure of mice to 2G for 24 h resulted in a significant increase of serum VEGF level, although expression of COX-2 and VEGF in the heart decreased to the 1G-control level. Moreover, increase of serum VEGF was not suppressed by treatment with COX-2 inhibitor, indicating that VEGF was induced in a COX-2-independent manner. These results suggest that gravitational force contributes to maintenance of the serum VEGF level.

• 日本実験動物学会 = Japanese Association for Laboratory Animal Scienceの論文

著者

• Oshima Hiroko

  Division Of Genetics Cancer Research Institute Kanazawa University

• Oshima Masanobu

  Division Of Genetics Cancer Research Institute Kanazawa University

• Suzki Hiromi

  Japan Space Forum

• Guo Xiaoying

  Division of Genetics, Cancer Research Institute, Kanazawa University

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