An Optimal Embryo Transfer Condition for the Effective Production of DBA/2J Mice

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概要

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• The DBA/2J mouse strain is a standard laboratory strain that is widely used for biomedical research. This strain, however, suffers from poor reproductive performance. In addition, the conditions for reliable embryo transfer (ET) of this strain have not been elucidated. The intention of this study was to determine the optimal number of embryos for transfer that allow the effective production of DBA/2J offspring. In the experiment, 7 to 15 embryos per oviduct were transferred into pseudopregnant ICR females. A relatively high success rate for pup production was observed when a large number of DBA/2J embryos (30 embryos per female) were transferred. This result shows that the ET efficiency of the DBA/2J strain can be improved by increasing the number of transferred embryos.

著者

• KOBAYASHI Kimio

  Functional Genomics Research Group, RIKEN Genomic Sciences Center (GSC)

• WAKANA Shigeharu

  Functional Genomics Research Group, RIKEN Genomic Sciences Center

• NAKAMURA Chika

  Functional Genomics Research Group, RIKEN Genomic Sciences Center

• SHIROISHI Toshihiko

  Functional Genomics Research Group, RIKEN Genomic Sciences Center

• KANEDA Hideki

  Functional Genomics Research Group, RIKEN Genomic Sciences Center

• TAGUMA Kyuichi

  Functional Genomics Research Group, RIKEN Genomic Sciences Center

• SUZUKI Chigusa

  Functional Genomics Research Group, RIKEN Genomic Sciences Center

• OZAKI Ai

  Functional Genomics Research Group, RIKEN Genomic Sciences Center

• HACHISU Akiko

  Functional Genomics Research Group, RIKEN Genomic Sciences Center

関連論文

• A large-scale mouse ENU mutagenesis for developing models of human common diseases
• An Optimal Embryo Transfer Condition for the Effective Production of DBA/2J Mice

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