Chronic Hepatotoxicity of Carbon Tetrachloride in HSP-70 Knock Out Mice

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概要

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• The chronic hepatotoxic effects of carbon tetrachloride (CCl4) in heat-shock protein (HSP) 70 knock out (HSP70-/-) mice were examined. After repeated intraperitoneal injections of CCl4 for six weeks, the level of ALT and weight ratio of the liver to body were lower in HSP70-/- mice than in the control (WT) mice. The levels of HSP25 and HSP47 were lowered in HSP70-/- mice as compared with WT mice. The grades of hepatic necrosis and neutrophil infiltration were not significantly different between HSP70-/- and WT mice. The collagen content was not affected significantly by CCl4 treatment.

• 社団法人　日本実験動物学会の論文
• 2004-01-01

著者

• Lee Min-jae

  Department Of Pathology College Of Medicine Seoul National University

• Lee Min-jae

  韓国

• JANG Ja-June

  Department of Pathology, School of Medicine, Seoul National University

• Jang Ja-june

  Department Of Pathology College Of Medicine Seoul National University

• LEE Mi-Sook

  Department of Bioimaging, Korea Basic Science Institute

• Lee Mi-sook

  Department Of Pathology College Of Medicine Seoul National University

• Kwon Myung-sang

  Laboratory Of Immunopharmacology Department Of Veterinary Medicine Kangwon National University

• Lee Yun-lyul

  Department Of Pysiology College Of Medicine Hallym University

• PARK Dae-Hun

  Laboratory of Immunopharmacology, Department of Veterinary Medicine Kangwon National University

• KIM Heui-Jin

  Diagnostic Lab., National Veterinary Research and Quarantine Service

• KIM Han-Seong

  Department of Anatomic Pathology, Inje University Ilsan Paik Hospital

• Kim Heui-jin

  Diagnostic Lab. National Veterinary Research And Quarantine Service

• Kim Han-seong

  Department Of Anatomic Pathology Inje University Ilsan Paik Hospital

• Lee Min-jae

  Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo

• Lee Mi-sook

  Department Of Bioimaging Korea Basic Science Institute

• Park Dae-hun

  Laboratory Of Immunopharmacology Department Of Veterinary Medicine Kangwon National University

• Kim Haui-Jin

  Diagnostic Lab., National Veterinary Research and Quarantine Service

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