Diabetes Mellitus Has an Additional Effect on Coronary Artery Disease. To Decrease Plasma Adiponectin Levels:To Decrease Plasma Adiponectin Levels

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概要

• 論文の詳細を見る

• We investigated whether plasma levels of adiponectin in patients with both coronary artery disease (CAD) and diabetes mellitus (DM) are lower than in patients with CAD alone. We examined plasma adiponectin levels in 113 patients, 82 with CAD (40 of whom had both CAD and type 2 DM) and 31 normal controls. We found differences in plasma adiponectin levels between CAD patients with and without DM (7.8 ± 4.75 versus 12.1 ± 6.87 μg/mL, P = 0.002), between patients with CAD and controls (10.0 ± 6.27 versus 15.3 ± 5.38 μg/mL, P < 0.0001), and between men and women (10.2 ± 6.41 versus 13.1 ± 6.22 μg/mL, P = 0.017). Plasma adiponectin levels were correlated negatively with body mass index, triglyceride, total cholesterol, hemoglobin A1c, and fibrinogen levels (r = -0.456, P < 0.0001 ; r = -0.355, P < 0.0001 ; r = -0.286, P = 0.002; r = -0.299, P < 0.0001 ; r = -0.400, P < 0.0001, respectively), but were not significantly correlated with high sensitivity C-reactive protein or low density lipoprotein levels (r = -0.088, P = 0.352; r = -0.167, P = 0.077, respectively). Plasma adiponectin levels correlated positively with high density lipoprotein levels (r = 0.410, P < 0.0001). Our study demonstrates that plasma adiponectin levels in patients with both CAD and DM are lower than in patients with CAD alone. We speculate that people who have very low plasma adiponectin levels may be at increased risk of developing both CAD and DM.

• International Heart Journal刊行会の論文

著者

• Huang Chien-ning

  Department Of Internal Medicine Chung-shan Medical University Hospital Chung-shan Medical University

• WU Der-Jinn

  Department of Internal Medicine, Chung Shan Medical and Dental College Hospital

• Huang Chien-Ning

  Department of Internal Medicine, Institute of Medicine, Chung-Shan Medical University Hospital

• Chan Kuei-Chuan

  Department of Internal Medicine, Institute of Medicine, Chung-Shan Medical University Hospital

• Chou Hsi-Hsien

  Department of Internal Medicine, Institute of Medicine, Chung-Shan Medical University Hospital

• Wu Yi-Liang

  Department of Internal Medicine, Institute of Medicine, Chung-Shan Medical University Hospital

• Chan Kuei-Chuan

  Department of Internal Medicine, Chung-Shan Medical University Hospital

• Wu Der-Jinn

  Department of Internal Medicine, Institute of Medicine, Chung-Shan Medical University Hospital

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