The Effect of Tirofiban on ST Segment Resolution in Patients With Non-ST Elevated Myocardial Infarction

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概要

• 論文の詳細を見る

• ST segment resolution in ST elevated myocardial infarction has independent predictive value for congestive heart failure and death at 30 days.1-2) ST segment depression in unstable angina pectoris (UAP) and non-ST elevated myocardial infarction (NSTEMI) predicts high risk of MI and death and may discriminate patients likely to have greater benefit from aggressive antithrombotic and interventional therapy.5-6) This study assessed the effect of tirofiban added to conventional treatment on ST segment resolution in NSTEMI patients. Sixty-four patients were randomized to one of the two groups: 32 patients received conventional treatment while tirofiban was added in the second group of 32 patients. In the first group, 6 patients refused to participate further after giving initial informed consent while 1 patient in the tirofiban group dropped out. We had 26 patients (mean age, 59 years) in the conventional treatment group and 31 patients (mean age, 59 years) received also tirofiban. Tirofiban was administered by intravenous infusion over a 72 hour period. More than 50% regression of depression was considered to be ST segment resolution. The characteristics of the two groups were comparable (Table I). The ST segment resolution evolution did not differ at the 4th and 24th hours between the two groups. Significant differences occurred in the 72nd hour ECG (Table III). ST resolution was present in 67.9% of the tirofiban patients and in 32.1% of the conventional treatment group (P < 0.05). Tirofiban treatment was not associated with an increase in major bleeding even though there was a trend toward an increase in minor bleeding cases and did not influence the occurrence of refractory angina pectoris.

• International Heart Journal刊行会の論文

著者

• Tikiz Hakan

  Department Of Cardiology Celal Bayar University Medical Faculty

• Tezcan Ugur

  Departments of Cardiology, University Hospital of Celal Bayar

• Eser Erhan

  Public Health Department, Faculty of Medicine, Celal Bayar University

• Eser Erhan

  Public Health, University Hospital of Celal Bayar

• Bayturan Özgür

  Departments of Cardiology, University Hospital of Celal Bayar

• Bilge Ali

  Departments of Cardiology, University Hospital of Celal Bayar

• Seküri Cevad

  Departments of Cardiology, University Hospital of Celal Bayar

• Ütük Ozan

  Departments of Cardiology, University Hospital of Celal Bayar

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• The Effect of Tirofiban on ST Segment Resolution in Patients With Non-ST Elevated Myocardial Infarction

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