Norepinephrine-induced Inositol 1,4,5-Trisphosphate Formation in Atrial Myocytes is Regulated by Extracellular Calcium, Protein Kinase C, and Calmodulin
スポンサーリンク
概要
- 論文の詳細を見る
We investigated whether alteration of extracellular and intracellular Ca2+ concentrations, protein kinase C, and calmodulin modulate norepinephrine(NE)-induced inositol 1,4,5-trisphosphate (IP3) formation in neonatal rat atrial myocytes. NE-induced IP3 production in atrial myocytes was stimulated by elevation of extracellular Ca2+ in a dose-dependent manner. However, TMB-8 (an intracellular calcium antagonist) and A23187 (an intracellular calcium agonist) did not significantly affect NE-induced IP3 production. PMA (a protein kinase C agonist) significantly decreased and staurosporine (a protein kinase C antagonist) significantly stimulated NE-induced IP3 production. W7 (a calmodulin antagonist) significantly increased the NE-induced IP3. In conclusion, elevation of extracellular Ca2+ concentrations affects NE-induced IP3 formation in atrial myocytes. Protein kinase C and calmodulin may control the IP3 response to NE by a negative feedback mechanism.
- International Heart Journal刊行会の論文
著者
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Kudoh Akira
Department Of Anesthesiology Hirosaki National Hospital
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Katagai Hiroshi
Department Of Anesthesiology Hirosaki National Hospital
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Takazawa Tomoko
Department of Anesthesiology, Hirosaki National Hospital
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Kudoh Emiko
Department of Pediatrics, Hirosaki National Hospital
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- Norepinephrine-induced Inositol 1,4,5-Trisphosphate Formation in Atrial Myocytes is Regulated by Extracellular Calcium, Protein Kinase C, and Calmodulin