Effects of Enoxaparin and Nadroparin on Major Cardiac Events in High-risk Unstable Angina Treated With a Glycoprotein IIb/IIIa Inhibitor.

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概要

• 論文の詳細を見る

• Clinical trials have reported the beneficial effects of platelet glycoprotein (GP) IIb/IIIa receptor antagonists and low-molecular-weight heparins (LMWH) on major cardiac events (MACE) in patients presenting with unstable angina or non-ST elevation myocardial infarction. A number of studies have documented the significant superiority of low-molecular-weight heparins, especially enoxaparin, over unfractionated heparin in the treatment of acute coronary syndromes. The purpose of this study was to compare the effects of two different LMWHs, enoxaparin and nadroparin, accompanied by platelet GP IIb/IIIa inhibition on MACE in high-risk unstable angina. The study was designed as an open-label and observational study. Sixty-eight patients presenting with unstable angina associated with high-risk criteria were randomly assigned to treatment with enoxaparin plus tirofiban (36 patients, mean age 57 ± 11) or nadroparin plus tirofiban (32 patients, mean age: 58 ± 8). In-hospital MACE including acute myocardial infarction (AMI), recurrent refractory angina, death, stroke, and urgent revascularization were compared between the study groups. Patient characteristics and durations of LMWH and tirofiban treatments were not different between the study groups. Coronary artery risk factors, except family history (which was observed more frequently in the enoxaparin group, P = 0.02), were also similar. MACE between the enoxaparin and nadroparin groups including AMI (5.5%, 6%), recurrent refractory angina (19%, 12%), death (0%, 3%), stroke (was not observed in either group), urgent revascularization (14%, 12%) and total MACE (19%, 15%) were not different. Enoxaparin and nadroparin, accompanied by GP IIb/IIIa inhibitor therapy, have similar effects on the development of major cardiac events in patients presenting with unstable angina and high-risk characteristics.

• International Heart Journal刊行会の論文

著者

• Tartan Zeynep

  Department Of Cardiology Siyami Ersek Cardiovascular And Thoracic Surgery Center

• Uyarel Huseyin

  Department Of Cardiology Siyami Ersek Cardiovascular And Thoracic Surgery Center

• Cam Nese

  Department Of Cardiology Dr. Siyami Ersek Thoracic And Cardiovascular Surgery Training And Research Hospital

• Ozen Ersin

  Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center

• Okmen Ertan

  Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center

• Sanli Arda

  Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center

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