Genetic Analysis of Reproduction in the Buryat Populations

概要

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A complex anthropological survey based on population-genetic methods and a study of a wide spectrum of genetic systems (43 alleles from 17 independent loci) was undertaken among 450 Buryat women of post-reproductive age. The results obtained showed the influence of particular genetic markers and their complex on the formation of peculiarities in the reproduction structure of the Buryat population. A sharp increase in phenotype GC 2-2 frequency and the corresponding GC^*2 allele of the group-specific component (GC) was established for women groups with burdened obstetric records. These groups are characterized also by a considerable decrease in the observed geterozygosity (H_o) as compared to its expected value (H_e). Samples including women with multiple pregnancies in the recorded obstetric anamnesis are characterized by a significant increase in the frequency of the rare alleles TF^*C3 of the transferrin system and those of PI^*Z belonging to the proteinase inhibitor system (a_1-antitrypsin) as compared to the control group. The results obtained widened current knowledge about the influence of genetic and environmental components on reproduction processes in human populations.
日本生理人類学会の論文