Frequent DNA Methylation but not Mutation of the ID4 Gene in Malignant Lymphoma
スポンサーリンク
概要
- 論文の詳細を見る
ID4 is a member of the inhibitor of DNA binding (ID) family, and inhibits the binding of basic helix-loop-helix transcription factors to DNA. In some malignant tumors, ID4 is inactivated by promoter hypermethylation, and is thought to be a candidate tumor suppressor gene (TSG). We have found that the promoter region of the ID4 gene is frequently methylated in lymphoid cell lines (100%, 9/9), primary diffuse large B-cell lymphoma (95%, 19/20), and follicular lymphoma (100%, 10/10). Somatic mutation of the ID4 gene was also examined, and no mutations were found. These findings suggest that the ID4 gene might be inactivated by DNA hypermethylation, and may function as a TSG in malignant lymphoma. [J Clin Exp Hematopathol 47(1) : 15-18, 2007]
著者
-
Ohashi Haruhiko
Clinical Research Center For Blood Disease National Hospital Organization Nagoya Medical Center
-
Nagai Hirokazu
Clinical Research Center National Hospital Organization Nagoya Medical Center
-
Hotta andHidehiko
Clinical Research Center for Blood Diseases, National Hospital Organization Nagoya Medical Center
-
Hagiwara Kazumi
Clinical Research Center for Blood Diseases, National Hospital Organization Nagoya Medical Center
-
Li Yinghua
Clinical Research Center for Blood Diseases, National Hospital Organization Nagoya Medical Center
-
Ohashi Haruhiko
Clinical Research Center for Blood Diseases, National Hospital Organization Nagoya Medical Center
-
Nagai Hirokazu
Clinical Research Center for Blood Diseases, National Hospital Organization Nagoya Medical Center
関連論文
- Promoter Hypermethylation of the DNA-Repair Gene O^6-Methylguanine-DNA Methyltransferase and p53 Mutation in Diffuse Large B-Cell Lymphoma
- Loss of O^6-Methylguanine-DNA Methyltransferase Protein Expression Is a Favorable Prognostic Marker in Diffuse Large B-Cell Lymphoma
- Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia in first complete-remission
- Donor cell leukemia after allogeneic peripheral blood stem cell transplantation : a case report and literature review
- Two rare MPL gene mutations in patients with essential thrombocythemia
- The status of antithymocyte globulin therapy for adult patients in Japan : retrospective analysis of a nationwide survey
- Successful Nonmyeloablative Bone Marrow Transplantation for Leukocyte Adhesion Deficiency Type I from an Unrelated Donor
- Characterization of myelodysplastic syndrome and aplastic anemia by immunostaining of p53 and hemoglobin F and karyotype analysis : Differential diagnosis between refractory anemia and aplastic anemia
- Actual status of AIDS-related lymphoma management in Japan
- Multicenter phase II study of bendamustine for relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma
- Frequent DNA Methylation but not Mutation of the ID4 Gene in Malignant Lymphoma
- Phase I and II study of azacitidine in Japanese patients with myelodysplastic syndromes
- Prognosis of mature T cell lymphoma is poorer than that of diffuse large B cell lymphoma in IPI low-risk group, but not in intermediate- and high-risk groups