Enhancement of bleomycin-induced chromosome damage in a human leukemic T-cell line

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概要

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• A sensitivity to bleomycin was examined in a human leukemic T-cell line (CCRF-HSB2) established from the peripheral blood of a patient with acute lymphoblastic leukemia. At all concentrations of bleomycin tested, HSB2 showed reduced survival and increased chromosome breakage. A normal B-cell line (KS86) and a radiation-insensitive CCRF-HSB2-M cell line were found to be resistant against the effects of bleomycin. The increased sensitivity of the human leukemic T-cell line (HSB2) to bleomycin, as well as to radiation (Shiraishi et al. 1976, 1978; Taguchi and Shiraishi 1983), indicates that HSB2 resembles to ataxia telangiectasia cells in their susceptibility to chromosomal aberration-inducing treatments.

著者

• TAGUCHI Takahiro

  Laboratory of Cytogenetics, Department of Anatomy, Kochi Medical School

関連論文

• Enhancement of bleomycin-induced chromosome damage in a human leukemic T-cell line

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