マウスにおける突然変異gracile axonal dystrophy(gad)遺伝子座の位置決定(第5染色体)〔英文〕

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概要

• 論文の詳細を見る

• Linkage tests of gracile axonal dystrophy (gad), an autosomal neurological mutation in the mouse, have shown that gad was located on chromosome 5 and linked to Pgm-1 and W. On the basis of the backcross data, the following recombination frequencies were calculated: Pgm-1-gad, 3.0±1.0 percent; W-gad, 5.4±2.6 percent. Therefore, the gene order was estimated to be centromere-gad-Pgm-1-W. Since Pgm-1 was closely linked to gad, Pgm-1 is a useful marker to recognize homozygotes (gad/gad) before onset of clinical signs and detect carriers (gad/+).

• Genetics Society of Japanの論文

著者

• Kikuchi Tateki

  Division Of Animal Models For Human Disease National Institute Of Neuroscience Ncnp

• TOMITA Takeshi

  Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University

• 山崎 一斗

  Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University

• 榊原 朱美

  Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University

• 富田 武

  Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University

• MUKOYAMA Masakuni

  Division of Degenerative Neurological Disease National Institute of Neuroscience

• YAMAZAKI Kazuto

  Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University

• KIKUCHI Tateki

  Division of Animal Models for Human Disease, National Institute of Neuroscience

関連論文

• ADAM22 deficient mice exhibit severe ataxia
• The Development of Laboratory Animal Science for the Study of Human Muscular and Nervous Diseases in Japan
• マウスにおける突然変異gracile axonal dystrophy(gad)遺伝子座の位置決定(第5染色体)〔英文〕

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