Mutagenicity of cyclophosphamide in mammalian cells treated in vitro and in utero.

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概要

• 論文の詳細を見る

• Chinese hamster V79 cells were treated with cyclophosphamide (CP) and various concentrations of S-15 mix in vitro, and then examined for chromosome aberrations, sister chromatid exchange (SCE) and induction of 8-azaguanine (8AG)-resistant mutations. Cells from hamster embryos treated with CP in utero by intraperitoneal injection were tested for drug-resistant mutation. CP caused a marked dose-dependent increase of chromosome aberrations, SCE and drug resistant mutations in V79 cells in the presence of lower concentrations of S-15. The inductions of 8AG-resistant mutations in V79 cells by CP with 1% S-15 were 7.4 times higher than those in the control. Trans- placentral treatment with CP also caused a marked increase in 8AG-resistant mutations of hamster embryonic cells.

• 日本遺伝学会の論文

著者

• KADA Tsuneo

  National Institute of Genetics

• Inui Naomichi

  Biological Research Center Japan Tobacco And Salt Public Corp.

• INUI Naomichi

  Biological Research Center, The Japan Tobacco and Salt Public Corporation

• SHIBUYA Hiroko

  Biological Research Center, The Japan Tobacco and Salt Public Corporation

• NISHI Yoshisuke

  Biological Research Center, The Japan Tobacco and Salt Public Corporation

関連論文

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• Antimutagenic Diterpenoids from a Crude Drug Isodonis Herba (Enmei-So)
• Cinnamaldehyde: Identification of an Antimutagen from a Crude Drug, Cinnamoni Cortex
• Mutagenicity of cyclophosphamide in mammalian cells treated in vitro and in utero.

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