N-ethyl-N-nitrosoureaによって誘発されたマウス突然変異体の遺伝学的解析〔英文〕

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概要

• 論文の詳細を見る

• Specific locus tests of the effects of N-ethyl-N-nitrosourea (ENU) on mouse spermatogonia using visible loci and hemoglobin beta-chain (Hbb) locus have been performed. Male wild-type (C3Hf/He) mice were injected intraperitoneally with ENU. Eight weeks after injection, the males were mated with tester strain females (PW) homozygous for six visible recessive genes. Ten visible and 2 hemoglobin mutants were obtained. The mutation frequency was 60.3×10-5/locus/generation. These mutations were all heritable, and nine out of ten mutations were viable under homozygous conditions. The results suggest that the mutations induced by ENU on spermatogonia of mice might have resulted from events at the genic rather than the chromosomal level.

• 日本遺伝学会の論文

著者

• 室田 哲郎

  Laboratory of Genetics, Hatano Research Institute

• 渋谷 徹

  Laboratory of Genetics, Hatano Research Institute

• SHIBUYA Tohru

  Laboratory of Genetic Toxicology, Hatano Research Institute, Food and Drug Safety Center

• MUROTA Tetsuro

  Laboratory of Genetics, Hatano Research Institute

• SHIBUYA Tohru

  Laboratory of Genetics, Hatano Research Institute

関連論文

• N-ethyl-N-nitrosoureaによって誘発されたマウス突然変異体の遺伝学的解析〔英文〕
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• 日本鶏におけるCp遺伝子の作用〔英文〕
• ニワトリの短脚突然変異遺伝子による致死作用の発現について〔英文〕

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