A new allele of the tottering locus, rolling mouse Nagoya, on chromosome no. 8 in the mouse.

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概要

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• Mating experiments showed that the rolling gene, rol, causing abnormal locomotor activity was an allele of the tottering, tg, locus and that this locus was closely linked to the non-specific esterase-1 locus on chromosome no. 8. As a consequence, it is demonstrated that the tg locus has three mutant alleles; tottering, tg, leaner, la, and rolling, rol. The mice with genotype rol/tg show clinical symptoms similar to rol/rol rather than to tg/tg. The symptom of ataxia occurs at about two weeks of age in this mutant, which survives to the adult age.

• 日本遺伝学会の論文

著者

• ODA Sen-ichi

  Research Institute of Environmental Medicine, Nagoya University

関連論文

• A new allele of the tottering locus, rolling mouse Nagoya, on chromosome no. 8 in the mouse.

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