GENETIC BACKGROUND AND EXPRESSIVITY OF CONGENITAL CATARACT IN MICE

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概要

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• Cataractous mice (Cts/Cts homozygotes) were reciprocally crossed with 4 inbred strains of mice. In F1, expressivity of the gene fluctuated depending upon the background genes. Expressivity of the gene in F1 was different from that in their F2, reflecting the heterogeneous genetic constitution of the latter. The Cts gene possessed complete penetrance, as might be expected of an autosomal semidominant gene. The initial sign of cataract formation was found at prenatal day 15 in the lens fibers near the anterior pole area of Cts/Cts homozygotes.

• 日本遺伝学会の論文

著者

• SEMBA REIJI

  Institute for Developmental Research

• SHOJI RYUJIRO

  Institute for Developmental Research

• HARATA MASAYO

  Institute for Developmental Research

関連論文

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• Contribution of Nitric Oxide-Producing Cells in Normal and Diabetic Rat Retina
• GENETIC BACKGROUND AND EXPRESSIVITY OF CONGENITAL CATARACT IN MICE

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