Interaction of the T10r mutation and lethal t-haplotypes on the chromosome 17 of the mouse.

概要

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The short-tailed mutation (T10r) induced by X-irradiation is allelic to the Brachyury (T) on chromosome 17 of the mouse. Embryos homozygous for the T10r are arrested developmentally at an earlier stage than T/T embryos, but T10r/T embryos are indistinguishable from the T/T. Serological studies suggest that the T10r for may be a deletion. The present study examined genetic interaction of the T10r and lethal t-haplotypes (tw32, t1, tw5, tw18, and tw1). The T10r/tn heterozygotes gave rise to viable tailless mice. Therefore, the T10r is similar to the T in interaction with recessive lethal t-haplotypes. Lethality factors of such t-haplotypes are mapped outside the abnormal region of T10r.
日本遺伝学会の論文