デオキシヌクレオシド三燐酸の効果について (X線誘起染色体切断の再結合におよぼす要因に関する研究-1・2-〔英文〕)

概要

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The combination experiments of X-irradiation with some mixture solutions of various nucleotides were undertaken with the chromosomes of the ovular tissue cells of Trillium kamtschaticum.Thymidine triphosphate did neither reduce nor increase significantly both frequencies of simple and rejoined breaks produced by X-rays. An equimolar mixture solution of three deoxyribonucleotides of dATP, dGTP and dCTP did not also result in any significant difference in the frequency of breaks from the X-ray control.When the four components commonly found in DNA or RNA were supplied as the form of nucleoside or nucleotide, there was a tendency toward the decrease of the frequency of breaks. The significant decrease in the frequency of simple breaks from that of the X-ray control was recognized in the three cases of (dATP+dGTP+dCTP+dTTP)+, (dATP+dGTP+dCTP+UTP)+, and (ATP+GTP+CTP+dTTP)+X-ray treatments.These results suggest the involvement of DNA synthesis in the process of reunion of X-ray-induced breaks, at least in restitution to restore the original continuity of chromosomes.
日本遺伝学会の論文