マウスにおけるレチノイン酸核内レセプタ-RARα,RARβ,RARγの遺伝子座マッピング〔英文〕
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概要
- 論文の詳細を見る
Nuclear retinoic acid receptors RARα, RARβ and RARγ are transcription factors that bind all-trans retinoic acid as their ligand and mediate its action by activating particular set of genes that contain retinoic acid responsive elements in their promoter-enhancers. We have mapped genetic loci for these genes using restriction fragment length variants (RFLVs) in interspecific backcross mice. None of the Rar loci cosegregated with each other or with the new subclass of retinoid receptors, Rxr loci. Rara mapped to mChr 11, Rarb mapped to mChr 14, and Rarg mapped to mChr 15. The results are consistent with the previous reports and the human data in terms of syntenic homology between mouse and human chromosomes.
- 日本遺伝学会の論文
- 1993-06-25
著者
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Seldin Michael
Department Of Microbiology And Immunology And Department Of Medicine Duke University Medical Center
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TAKETO Makoto
Department of Pharmacology, Kyoto University Graduate School of Medicine
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Taketo Makoto
Department Of Microbiology And Immunology And Department Of Medicine Duke University Medical Center
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HOOPES Charles
Department of Microbiology and Immunology, and Department of Medicine, Duke University Medical Cente
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HOWARD Thad
Department of Microbiology and Immunology, and Department of Medicine, Duke University Medical Cente
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LINNEY Elwood
Department of Microbiology and Immunology, and Department of Medicine, Duke University Medical Cente
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Howard Thad
Department Of Microbiology And Immunology And Department Of Medicine Duke University Medical Center
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Linney Elwood
Department Of Microbiology And Immunology And Department Of Medicine Duke University Medical Center
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Hoopes Charles
Department Of Microbiology And Immunology And Department Of Medicine Duke University Medical Center
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武藤 誠
Department Of Cardiology Saitama Prefecture Cardiovascular Respiratory Center
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Hoopes C.
Department of Microbiology and Immunology, and Department of Medicine, Duke University Medical Center
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Howard T.A.
Department of Microbiology and Immunology, and Department of Medicine, Duke University Medical Center
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