突然変異誘発物質による架橋と染色体切断能力との相関の可能性の続報〔英文〕

概要

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The frequencies of sex-linked lethals and translocations were determined in the progeny of Drosophila _??__??_ injected with either ethylene imine or TEM [2:4:6-tri (ethyleneimino)-1:3:5-triazine]. The ratio of translocations to lethals was the smallest in the case of TEM treatment. The results agree very closely with the data obtained with ethylene oxide and diepoxybutane as expected in the previous paper (Nakao and Auerbach 1961). This, again, lends no support to the idea that the difference in carcinostatic activity between monofunctional and polyfunctional alkylating agents is due to cross-linking action of the latter type of compound on the chromosome. TEM did in fact induce fewer translocations that expected from the number of functional arms. Possible cause for this result and related problems were discussed.