雌ラットにおけるアロキサン第4脳室内投与がパルス状黄体形成ホルモン分泌に及ぼす影響
スポンサーリンク
概要
- 論文の詳細を見る
Previous studies have suggested the presence of a glucose-sensing mechanism in the hindbrain that appears to regulate reproductive function as well as feeding behavior. The ependymocytes lining the ventricular wall of the hindbrain showed immunoreactivities to pancreatic glucokinase (GK), a key enzyme for glucose sensing in pancreatic B cells. Our goal in the present study was to test whether the GK-immunopositive ependymocytes in the wall of the fourth cerebroventricle (4V) play a role in regulating gonadal activity. Our approach was to determine the effect of injecting alloxan, a GK inhibitor, into the 4V on pulsatile luteinizing hormone (LH) secretion. Estrogen-primed ovariectomized rats received an injection of alloxan (10 or 20 μg/animal) into the 4V and blood samples were collected every 6 min for 3 h for measurement of blood LH, corticosterone and glucose levels. Pulsatile LH secretion was suppressed after alloxan injection and all pulse parameters were significantly (P<0.05) inhibited by 20 μg alloxan. Plasma corticosterone levels were increased significantly (P<0.05) by 20 μg alloxan, suggesting that LH pulse suppression by alloxan may be at least partly mediated by activation of the hypothalamo-pituitary-adrenal axis. The present results suggest that acute suppression of GK activity in the hindbrain inhibits pulsatile LH secretion in female rats, and supports the idea that GK-immunopositive ependymocytes may sense glucose levels in the cerebrospinal fluid and play a role in regulation of LH secretion.
- 日本繁殖生物学会の論文
著者
-
MAEDA Kei-ichiro
Graduate School of Bioagricultural Sciences, Nagoya University
-
木下 美香
Graduate School of Bioagricultural Sciences, Nagoya University
-
束村 博子
Graduate School of Bioagricultural Sciences, Nagoya University
関連論文
- シバヤギにおける絶食および再給餌期間中のGnRHパルスジェネレーター活動と血中代謝基質およびインスリン濃度変化との対応関係
- Acute Lipoprivation Suppresses Pulsatile Luteinizing Hormone Secretion without Affecting Food Intake in Female Rats
- PHARMACOLOGICAL BLOCKADE OF FATTY ACID OXIDATION SUPPRESSES LH SECRETION IN ADULT FEMALE RATS
- BRAINSTEM NORADRENERGIC (NA) INPUTS TO THE PARAVENTICULAR NUCLEUS (PVN) IS INVOLVED IN ESTROGEN RECEPTOR α (ERα) EXPRESSION DURING DIFFERENT STRESS CONDITIONS IN FEMALE RATS
- Prevention of inhibitory effect of dorsal raphe nucleus lesions on ovulation and LH surge by 5-HT 2A/2C receptor agonists in female rats
- GONADOTROPIN - RELEASING HORMONE - IMMUNOPOSITIVE CELLS IN THE PRIMARY CULTURES ORIGINATING FROM THE RAT FETAL TELENCEPHALIC OR DIENCEPHALIC REGIONS AND THEIR PULSATILE RELEASING ACTIVITIES
- Potencies of Centrally- or Peripherally-Injected Full-Length Kisspeptin or Its C-Terminal Decapeptide on LH Release in Intact Male Rats
- Neuroendocrine mechanism mediating energetic regulation of gonadotropin release in female rats
- ESTROGEN FEEDBACK SITES MEDIATING PREPUBERTAL LUTEINIZING HORMONE (LH) SUPPRESSION IN FEMALE RATS
- FEEDBACK EFFECT OF TESTOSTERONE ON PUBERTAL RISE IN LUTEINIZING HORMONE SECRETION IN MALE RATS
- A LONG-CHAIN FATTY ACID INDUCES INCREASE IN INTRACELLULAR CALCIUM CONCENTRATION IN THE PANCREATIC GLUCOKINASE-IMMUNOREACTIVE CELLS IN THE RAT MEDULLA OBLONAGATA
- GLUCOKINASE ACTIVITY IN EPENDYMOCYTES OF THE FOURTH VENTRICULAR IN FEMALE RATS
- THE EFFECT OF GLUCOSE INFUSION INTO THE DORSAL RAPHE NUCLEUS ON GLUCOPRIVIC SUPPRESSION OF PULSATILE SECRETION OF LUTEINIZING HORMONE IN THE RAT
- ROLE OF ATP AS A NEUROTRANSMITTER IN REGULATING REPRODUCTION IN THE BRAIN
- 雌ラットにおけるアロキサン第4脳室内投与がパルス状黄体形成ホルモン分泌に及ぼす影響
- 雌ラットにおけるアロキサン第4脳室内投与がパルス状黄体形成ホルモン分泌に及ぼす影響