デキサメサゾンによって誘起されるブタ卵巣へ投射する交感神経の変化と卵巣内ステロイド合成能の変化

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概要

• 論文の詳細を見る

• The aim of the present study was to determine changes in the density of sympathetic nerves in porcine ovaries with dexamethasone (DXM)-induced cysts and the alterations in steroidogenic activity and amounts of catecholamines in the affected gonads. Cystic ovaries were supplied by numerous sympathetic nerve fibers. The amount of noradrenaline in the cysts (fluid, wall) was significantly higher than in the large follicles of the control group. After DXM injections, the amounts of noradrenaline and adrenaline significantly increased in the walls of small and medium-sized follicles. In the cysts (fluid, walls) the levels of androgens and estrogens were significantly lower, whereas progesterone was higher in the cystic wall. DXM administration led to a significant increase in the estrone content in the fluid of small follicles. Moreover, a decrease in the amounts of progesterone and androgens was found in the follicular fluid and walls of medium-sized follicles. DXM injections resulted in a significant increase in the immunoexpression of P450scc and 3β-HSD in the cysts, a significant increase of P450scc in the follicles, and a decrease of 3β-HSD and P450arom. The present study shows that the DXM treatment leads to an increase in the density of intraovarian sympathetic nerves, paralleled by the amount of catecholamines, and that it is capable of changing the steroidogenic activity of porcine ovary bearing cysts. Thus, it appears possible that these events may be, at least partly, involved in the pathogenesis of this disorder.

• 日本繁殖生物学会の論文

著者

• PISKULA Mariusz

  Department of Food Technology, Institute of Animal Reproduction and Food Research, Polish Academy of

• Jana Barbara

  Division Of Reproductive Endocrinology And Pathophysiology Institute Of Animal Reproduction And Food

• DZIENIS Anna

  Division of Reproductive Endocrinology and Pathophysiology, Institute of Animal Reproduction and Foo

• ROGOZINSKA Anna

  Division of Reproductive Endocrinology and Pathophysiology, Institute of Animal Reproduction and Foo

• JEDLINSKA-KRAKOWSKA Maria

  Division of Pathophysiology, Department of Pathology and Pharmacology, Faculty of Veterinary Medicin

• WOJTKIEWICZ Joanna

  Division of Clinicial Physiology, Department of Functional Morphology, Faculty of Veterinary Medicin

• MAJEWSKI Mariusz

  Division of Clinicial Physiology, Department of Functional Morphology, Faculty of Veterinary Medicin

• Dzienis Anna

  Division Of Reproductive Endocrinology And Pathophysiology Institute Of Animal Reproduction And Food

• Rogozinska Anna

  Division Of Reproductive Endocrinology And Pathophysiology Institute Of Animal Reproduction And Food

• Piskula Mariusz

  Department Of Food Technology Institute Of Animal Reproduction And Food Research Polish Academy Of S

• Wojtkiewicz Joanna

  Division Of Clinicial Physiology Department Of Functional Morphology Faculty Of Veterinary Medicine

• Jedlinska-krakowska Maria

  Division Of Pathophysiology Department Of Pathology And Pharmacology Faculty Of Veterinary Medicine

• Majewski Mariusz

  Division Of Clinicial Physiology Department Of Functional Morphology Faculty Of Veterinary Medicine

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• Dexamethasone-induced Changes in Sympathetic Innervation of Porcine Ovaries and in Their Steroidogenic Activity
• デキサメサゾンによって誘起されるブタ卵巣へ投射する交感神経の変化と卵巣内ステロイド合成能の変化
• 酸化ストレス時のビタミンE及びC投与がラットの精巣形態に及ぼす影響
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