Tyrosinase Inhibitor Isolated from the Leaves of Zanthoxylum piperitum

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概要

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• Two flavonols, quercetin (1) and quercitrin (2), were isolated from the leaves of Zanthoxylum piperitum. Their structures were established by UV, one- and two-dimensional NMR, and mass spectroscopic methods. Quercetin showed significant inhibition against mushroom tyrosinase with an IC50 value of 3.8 μg/ml, and appeared to inhibit the polyphenol oxidase activity of tyrosinase in a competitive manner (Ki=10±0.20 μM) when L-tyrosine was used as a substrate, although it did not inhibit the melanin production of Streptomyces bikiniensis.

• 社団法人 日本農芸化学会の論文
• 2004-09-23

著者

• Shim Ki

  Division Of Applied Life Science Graduate School And Institute Of Agricultural Life Sciences Gyeongs

• Jeong Chang

  Division Of Applied Life Science Graduate School And Institute Of Agricultural Life Sciences Gyeongs

関連論文

• Tyrosinase Inhibitor Isolated from the Leaves of Zanthoxylum piperitum

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