Immunological Effects of Partially Hydrolyzed Arabinoxylan from Corn Husk in Mice

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概要

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• The effect of oral administration of partially hydrolyzed water-soluble corn husk arabinoxylan (CHAX), the average molecular weight of which is about 53 kDa, on immunopotentiating activity was investigated in mice. Oral administration of CHAX to healthy mice significantly augmented the production of interleukin (IL)-2 and interferon (IFN)-γ with a slight increase in IL-4 in mitogen-induced proliferation of spleen cells. Natural killer (NK) cell activity in spleen cells from mice, which were transplanted tumor and administrated CHAX, was augmented about 2-fold. In model mice of atopic dermatitis, the average ear thickness of mice administrated CHAX was induced by dinitrophenyl-fluorobenzene (DNFB) after injection of an anti-dinitrophenyl (DNP)-IgE monoclonal antibody was much smaller than that in control animals. These results suggest that CHAX has the ability to increase the level of immunopotentiating activity without causing over response of immunological reaction even if it is administrated orally to mice.

• 社団法人 日本農芸化学会の論文
• 2005-01-23

著者

• OGAWA Koichi

  Research Center for Frontier Medical Engineering, Chiba University

• TAKEUCHI Masayasu

  Research Institute, Nihon Shokuhin Kako Co., Ltd.

• Takeuchi Masayasu

  Research Institute Nihon Shokuhin Kako Co. Ltd.

• Ogawa Koichi

  Research Center For Frontier Medical Engineering Chiba University:communication Devices Development

• Ogawa Koichi

  Research Institute Nihon Shokuhin Kako Co. Ltd.

• NAKAMURA Nobuyuki

  Fine Chemicals Department, Nihon Shokuhin Kako Co., Ltd.

• Nakamura Nobuyuki

  Fine Chemicals Department Nihon Shokuhin Kako Co. Ltd.

関連論文

• Simple Modeling of an Abdomen of Pregnant Women and Its Application to SAR Estimation(Electromagnetic Compatibility (EMC))
• Digestion and Fermentation by Human Intestinal Bacteria of Corn Fiber and Its Hemicellulose in Vitro(Food & Nutrition)
• Effect of Corn Fiber on Fecal Flora, Properties of Feces, β-Glucuronidase, and Levels of Serum Lipid in Healthy Men(Food & Nutrition)
• Immunological Effects of Partially Hydrolyzed Arabinoxylan from Corn Husk in Mice
• Enzymatic Synthesis of p-Nitrophenyl α-Maltoheptaoside by Transglycosylation of Maltohexaose-forming Amylase(Biological Chemistry)

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