Molecular Cloning and Expression Analysis of Two Hepcidin Genes from Olive Flounder Paralichthys olivaceus
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概要
- 論文の詳細を見る
Hepcidin is a cysteine-rich cationic antimicrobial peptide central to iron metabolism. We report a comparative analysis of the sequences, gene organization and expression of two hepcidin genes from olive flounder Paralichthys olivaceus. Both consist of two introns and three exons that encode a prepropeptide (81 amino acids for hepcidin I and 89 amino acids for hepcidin II). A TATA box and several consensus-binding motifs for transcription factors were found upstream of the transcriptional starting site. Hepcidin II was predominantly expressed in the liver and highly inducible under the effect of lipopolysaccharide (LPS), while a large amount of hepcidin I transcripts was detected in various tissues but did not appear to have a significant effect during LPS-stimulation.
- 社団法人 日本農芸化学会の論文
- 2005-07-23
著者
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Lee Sang-jun
Biotechnology Research Center National Fisheries Research And Development Institute
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Lee Sang-jun
Biotechnology Division National Fisheries Research And Development Institute
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NAM Bo-Hye
National Fisheries Research and Development Institute
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Kim Kyung-kil
Biotechnology Research Center National Fisheries Research And Development Institute
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KIM Young-Ok
Biotechnology Research Institute, National Fisheries Research and Development Institute
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NAM Bo-Hye
Biotechnology Research Institute, National Fisheries Research and Development Institute
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HONG Suhee
Factory of Marine Bioscience and Technology, Kangnung National University
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LEE Jeong-Ho
Biotechnology Research Center, National Fisheries Research and Development Institute
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Kim Kyung-kil
Biotechnology Research Center National Fisheries Research & Development Institute (nfrdi)
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Lee Jeong-ho
Biotechnology Research Center National Fisheries Research And Development Institute
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Kim Kyung-kil
Biotechnology Research Institute National Fisheries Research And Development Institute
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Lee Sang-jun
Biotechnology Research Institute National Fisheries Research And Development Institute
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Hong Suhee
Factory Of Marine Bioscience And Technology Kangnung National University
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Nam Bo-hye
Biotechnology Research Division National Fisheries Research And Development Institute
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Kim Young-ok
Biotechnology Research Division National Fisheries Research And Development Institute
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NAM Bo-Hye
Biotechnology Research Center, National Fisheries Research and Development Institute
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KIM Young-Ok
Biotechnology Research Center, National Fisheries Research and Development Institute
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