An Inhibitor of Glucosylceramide Synthase Inhibits the Human Enzyme, but Not Enzymes from Other Organisms

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概要

• 論文の詳細を見る

• Specific inhibitors of glucosylceramide biosynthesis are used as drugs for the treatment of some human diseases correlated to glycosphingolipid metabolism. The target of the presently available inhibitors is the human glucosylceramide synthase (GCS), but effects on enzymes from other organisms have not been studied. We expressed cDNAs encoding GCS enzymes from lower animals, plants, fungi, and bacteria in the yeast P. pastoris. In vitro GCS assays with the GCS inhibitor D-threo-1-(3′,4′-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol showed that this inhibitor did not affect non-human GCS enzymes.

• 社団法人 日本農芸化学会の論文

著者

• WARNECKE Dirk

  Biozentrum Klein Flottbek, University of Hamburg

• HEINZ Ernst

  Biozentrum Klein Flottbek, University of Hamburg

• HILLIG Inga

  Biozentrum Klein Flottbek und Botanischer Garten, University of Hamburg

• WARNECKE Dirk

  Biozentrum Klein Flottbek und Botanischer Garten, University of Hamburg

関連論文

• Glycoengineering of Cyanobacterial Thylakoid Membranes for Future Studies on the Role of Glycolipids in Photosynthesis
• An Inhibitor of Glucosylceramide Synthase Inhibits the Human Enzyme, but Not Enzymes from Other Organisms

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