Characterization of the Promoter of the Mouse Preproorexin Gene

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概要

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• The neuropeptide Orexin is involved in the regulation of the sleep-awake cycle and feeding behavior. We isolated a 22-kb genomic clone containing the 5′ flanking region of the mouse Orexin promoter. We determined that the transcription start site (+1) is located 96 nucleotides upstream of the initiation codon. The start site region contained consensus sequences corresponding to the transcription initiator and TATA box. Analysis of promoter activity using PC12 cells showed that regions between −13 and +112 and between −1,868 and −780 contained nerve growth factor (NGF)-responsive positive regulatory element and a negative regulatory element respectively.

• 社団法人 日本農芸化学会の論文

著者

• Kida Satoshi

  Laboratory Of Developmental Biology Department Of Cellular Biology Institute Of Molecular And Cellul

• Hosoda Hiroshi

  Laboratory Of Animal Molecular Biology Department Of Bioscience Faculty Of Applied Bioscience Tokyo

• Fukuda Toru

  Laboratory Of Animal Molecular Biology Department Of Bioscience Faculty Of Applied Bioscience Tokyo

• KATO Haruno

  Laboratory of Animal Molecular Biology, Department of Bioscience, Faculty of Applied Bioscience, Tok

• MASUSHIGE Shoichi

  Laboratory of Animal Molecular Biology, Department of Bioscience, Faculty of Applied Bioscience, Tok

関連論文

• Restricted Expression of a Member of the Transcription Elongation Factor S-II Family in Testicular Germ Cells during and after Meiosis^1
• Characterization of the Promoter of the Mouse Preproorexin Gene
• Characterization of the Promoter of the Mouse Preproorexin Gene

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