Phylogenetic and Disruption Analyses of Aspartate Kinase of Deinococcus radiodurans

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概要

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• The extremely radioresistant bacterium Deinococcus radiodurans is evolutionarily closely related to the extremely thermophilic bacterium Thermus thermophilus. These bacteria have a single gene encoding an aspartate kinase (AK) that catalyzes the phosphorylation of L-aspartate. T. thermophilus has an aminoadipate pathway for lysine biosynthesis that does not use AK for lysine biosynthesis. Phylogenetic analysis in this study indicated that D. radiodurans AK has a different protein structure and a different evolutionary history from T. thermophilus AK. Disruption analysis of D. radiodurans AK indicated that D. radiodurans AK was not used for lysine biosynthesis but for threonine and methionine biosyntheses. A D. radiodurans AK disruption mutant exhibited a phenotype similar to a T. thermophilus AK disruption mutant, which indicates that these two AKs have different evolutionary origins, though their functions are not different.

• 社団法人 日本農芸化学会の論文

著者

• Nishida Hiromi

  Agricultural Bioinformatics Res. Unit Graduate School Of Agriculture And Life Sciences The Univ. Of

• Narumi Issay

  Radiation-applied Biology Division Quantum Beam Science Directorate Japan Atomic Energy Agency

関連論文

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• Phylogenetic and Disruption Analyses of Aspartate Kinase of Deinococcus radiodurans
• Phylogenetic and Disruption Analyses of Aspartate Kinase of Deinococcus radiodurans
• Optimization of ion-beam irradiation for mutagenesis in soybean: effects on plant growth and production of visibly altered mutants

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