Asymmetric Hydrolysis of (±)-1-Acetoxy-2, 3-dichloropropane with Enzymes and Microorganisms

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概要

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• Enzymes and microorganisms were screened for the enantioselective hydrolysis of (±)-1-acetoxy-2, 3-dichloropropane (1) which is convertible to epichlorohydrin. Pancreatin and steapsin from hog pancreas were found to hydrolyze (±)-1 asymmetrically to give (S)-1 of 90% enantiomeric excess (e.e.). From (S)-1 was synthesized the optically pure (S)-isomer of propranolol[1-isopropylamino-3-(1-naphthoxy)-2-propanol], one of the typical β-adrenergic blocking agents.

• 社団法人 日本農芸化学会の論文

著者

• IRIUCHIJIMA Shinobu

  Sagami Chemical Research Center

• KEIYU Atsuko

  Sagami Chemical Research Center

• KOJIMA Natsuko

  Sagami Chemical Research Center

関連論文

• Asymmetric Hydrolysis of Prochiral Diesters with Pig Liver Esterase. Preparation of Optically Active Intermediates for the Synthesis of ( + )-Biotin and (+)-α-Methyl-3, 4-dihydroxyphenylalanine
• Asymmetric Hydrolysis of (±)-1-Acetoxy-2, 3-dichloropropane with Enzymes and Microorganisms
• Stereochemical Studies on the Halogenation of Sulfoxides. II. The Bromination of Cyclic Sulfoxides
• Asymmetric Hydrolysis of (±)-1, 2-Diacetoxy-3-chloropropane and Its Related Compounds with Lipase. Synthesis of Optically Pure (S)-Propranolol

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