Cyanoacrylate Inhibitors of the Hill Reaction I. Nature of the Inhibitor/Receptor Site Interaction
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A series of alkyl 3-alkylamino-2-cyanoacrylates was synthesized and assayed as inhibitors of the Hill reaction in isolated pea chloroplasts. The results suggest that there is a single centre in these molecules, possibly the carbonyl group, which specifically interacts with the inhibitor receptor site and that maximum activity is associated with an asymmetric distribution about this centre of lipophilic alkyl groups which are involved in non-specific binding to discrete hydrophobic regions.
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