Local Anaesthetic Activity and Synthesis of 2-(N-Substituted or N, N-Disubstituted aminoacetamido)-4-aryl Thiazoles

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概要

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• Some new 2-(N-substituted or N, N-disubstituted aminoacetamido)-4-p-nitrophenyl, 4-m-nitrophenyl and 4-(2, 5-dimethoxy)phenyl thiazoles were synthesised. Their hydrochlorides were screened for local anaesthetic activity by Frogs sciatic plexus method and this activity compared with that of procaine hydrochloride. Among them, the 2-(N-substituted aminoacetamido)-4-m-nitrophenylthiazole hydrochlorides are the most potent: almost twice in terms of the onset of anaesthesia in comparison with procaine-HCl.

• 社団法人 日本農芸化学会の論文

著者

• Lakhan Ram

  Department Of Chemistry Faculty Of Science Banaras Hindu University

• SINGH Om

  Department of Chemistry, Faculty of Science, Banaras Hindu University

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• Local Anaesthetic Activity and Synthesis of 2-(N-Substituted or N, N-Disubstituted aminoacetamido)-4-aryl Thiazoles

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