Synthesis of 3, 6-di-O-Methylglucosyl Disaccharides with Methyl 3-(p-Hydroxyphenyl)propionate as a Linker Arm and Their Use in the Serodiagnosis of Leprosy

スポンサーリンク

概要

• 論文の詳細を見る

• The disaccharide, 2, 3-di-O-methyl-4-O-(3, 6-di-O-methyl-β-D-glucopyranosyl)-L-rhamnopyranose, the distal segment of phenolic glycolipid I, that is a specific antigen from Mycobacterium leprae, and some related disaccharides were synthesised as the glycosides of methyl 3-(p-hydroxyphenyl)propionate. The methyl 3-(p-hydroxyphenyl)propionate was coupled with 2, 3, 4-tri-O-acetyl-L-rhamnosyl bromide, deacetylated, acetonated, coupled with 2, 4, 6-tri-O-acetyl-3-O-methyl-D-glucosyl bromide, and converted into a variety of p-(2-methoxycarbonylethyl)phenyl 4-O-(3, 6-di-O-methyl-D-glucopyranosyl)-containing disaccharides that are amenable to ready conjugation with protein carriers, thereby providing neo-glycoconjugates for the specific serodiagnosis of leprosy.

• 社団法人 日本農芸化学会の論文

著者

• Izumi Shinzo

  Leprosy Study Group - Institute Of Tropical Disease Airlangga University

• FUJIWARA Tsuyoshi

  Laboratory of Chemistry, Institute for Natural Science, Nara University

• BRENNAN Patrick

  Department of Microbiology, Colorado State University

• IZUMI Shinzo

  Leprosy Research Laboratory, Department of Dermatology, Faculty of Medicine, Kyoto University

関連論文

• FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease
• Sialylation regulates peripheral tolerance in CD4+ T cells
• GENOTYPING ANALYSIS BY TTC REPEAT DIVERSITY OF M. leprae CLINICAL ISOLATES AND HOUSEHOLD CONTACTS IN LEPROSY ENDEMIC AREA (Genotyping study in Sampang, East Java Province, Indonesia)
• CORRELATION BETWEEN THE SERO-POSITIVITY LEVEL AND NEW CASE DETECTION RATE (NCDR) IN SOME LEPROSY ENDEMIC AREAS OF INDONESIA
• Synthesis of the Neoglycoconjugates of Phenolic Glycolipid-related Trisaccharides for the Serodiagnosis of Leprosy
• Synthesis of 3, 6-di-O-Methylglucosyl Disaccharides with Methyl 3-(p-Hydroxyphenyl)propionate as a Linker Arm and Their Use in the Serodiagnosis of Leprosy

スポンサーリンク