Inhibition of Farnesoic Acid Methyltransferase by Sinefungin

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概要

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• Sinefungin inhibited the S-adenosylmethionine-dependent farnesoic acid methyltransferase in a cell-free system containing a homogenate of corpora allata from female locusts, Locusta migratoria. The enzyme catalyzed the penultimate step of juvenile hormone biosynthesis in the insects. Culturing corpora allata in the presence of sinefungin greatly suppressed juvenile hormone production. The following in vivo effects were visible after injection of the inhibitor: increase in mortality and reduction of total haemolymph protein liter and ovary fresh weight, as well as length of terminal oocytes. Attempts to reverse these effects by topical application of the juvenile hormone analog ZR-515 (methoprene) were only partly successful. Therefore, the in vivo effects may be due to a general inhibition of methyltransferase enzymes in the insect. Sinefungin appeared to be of potential interest as the first representative of a new class of insect growth regulators.

• 社団法人 日本農芸化学会の論文

著者

• PETER Martin

  Institut für Organische Chemie und Biochemie der Universität Bonn

• FERENZ Hans-Jörg

  Fachbereich Biologie, Universität Oldenburg

• BERG Dieter

  Bayer AG, Sektor Landwirtschaft, Chemisette Forschung

関連論文

• Inhibition of Farnesoic Acid Methyltransferase by Sinefungin

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