Application of Microbes and Microbial Esterases to the Preparation of Optically Active N-Acetylindoline-2-Carboxylic Acid

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概要

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• Methylotrophic bacteria, isolated from soil samples or from sewage sludge, proved to be useful sources of esterases for catalyzing the enantioselective hydrolysis of racemic N-acetyl-indoline-2-carboxylic acid methyl ester (7) to the corresponding (2S) or (2R)-N-acetyl amino acid (6) with high optical yields. From the DMF-utilizer Pseudomonas DMF 5/8 and the methanol-utilizer Isolate EE 210, the corresponding esterases were isolated. Reactions with whole cells as well as with the purified enzymes are described.

• 社団法人 日本農芸化学会の論文

著者

• Ghisalba Oreste

  Central Research Laboratories Ciba-geigy Ag

• Schar Hans-peter

  Central Research Laboratories Ciba-geigy Ag

• TOMBO Gerardo

  Central Research Laboratories of CIBA-GEIGY AG

関連論文

• Diastereoselective Microbial Hydroxylation of Milbemycin Derivatives(Microbiology & Fermentation Industry)
• Application of Microbes and Microbial Esterases to the Preparation of Optically Active N-Acetylindoline-2-Carboxylic Acid

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