GroupAdaBoost: Accurate Prediction and Selection of Important Genes

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概要

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• In this paper, we propose GroupAdaBoost which is a variant of AdaBoost for statistical pattern recognition. The objective of the proposed algorithm is to solve the “ p » n ”problem arisen in bioinformatics. In a microarray experiment, gene expressions are observed to extract any specific pattern of gene expressions related to a disease status. Typically, p is the number of investigated genes and n is number of individuals. The ordinary method for predicting the genetic causes of diseases is apt to over-learn from any particular training dataset because of the“ p » n ” problem. We observed that GroupAdaBoost gave a robust performance for cases of the excess number p of genes. In several real datasets which are publicly available from web-pages, we compared the analysis of results among the proposed method and others, and a small scale of simulation study to confirm the validity of the proposed method. Additionally the proposed method effectively worked for the identification of important genes.

著者

• Ushijima Masaru

  Genome Center Japanese Foundation For Cancer Research

• Eguchi Shinto

  Institute Of Statistical Mathematics Japan And Department Of Statistical Science Graduate University

• Takenouchi Takashi

  Graduate School Of Information Science Nara Institute Of Science And Technology

関連論文

• Identifying haplotype block structure using an ancestor-derived model
• GroupAdaBoost : Accurate Prediction and Selection of Important Genes
• Genotyping of Single Nucleotide Polymorphisms Based on a Mathematical Model for Two-Dimensional Data
• COLLABORATIVE PREDICTION BY MULTIPLE BAYESIAN NETWORKS AND ITS APPLICATION TO PRINTER USAGE MODELING(Bayesian networks and their application)
• GroupAdaBoost: Accurate Prediction and Selection of Important Genes
• GroupAdaBoost: Accurate Prediction and Selection of Important Genes

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