Drug Concentration-Time Profile in the Plasma Following the Dissolution-Type Transdermal Delivery
スポンサーリンク
概要
- 論文の詳細を見る
In medical treatment, a constant plasma concentration for an extended period of time is preferable for some diseases, while pulsatile delivery or delayed delivery is also required to avoid the tolerance and set a delayed time for medication. The dissolution-type TTS is expected to achieve pulsatile delivery. In this work, a mathematical model was proposed for the prediction of the plasma concentration–time profile following the application of the dissolution-type TTS. In vivo animal data was compared with the simulated profile together with the model parameters determined independently. The calculated concentration–time profile well agreed with the in vivo animal data.
- 社団法人 化学工学会の論文
- 2003-01-01
著者
-
Tojo Kakuji
Graduate School Of Computer Sci. And Systems Engineering Kyushu Inst. Of Technol.
-
Mori Daisuke
Graduate School Of Computer Science And Systems Engineering Kyushu Institute Of Technology
-
Kawamata Hideki
Graduate School Of Computer Science And Systems Engineering Kyushu Institute Of Technology
関連論文
- Computational Fluid Dynamics Study of the Effect of the Left Ventricular Flow Ejection on the Intraaortic Flow(Cardiovascular Mechanics)
- Effect of Molecular Weight of Penetrants on Iontophoretic Transdermal Delivery In Vitro
- Synergistic Effect of Sonophoresis and Iontophoresis in Transdermal Drug Delivery
- Effect of Microdermabrasion on Barrier Capacity of Stratum Corneum
- Drug Penetration of the Posterior Eye Tissues after Topical Instillation: In Vivo and in Silico Simulation
- Drug Concentration-Time Profile in the Plasma Following the Dissolution-Type Transdermal Delivery
- Effect of Environmental Temperature on Transdermal Drug Penetration
- Microwave-Assisted Synthesis of Organometallic Complexes of 99mTc(CO)3 and Re(CO)3: Its Application to Radiopharmaceuticals