〈生命科学科〉胎生期にcytosine arabinoside を曝露されたマウスに誘発された行動異常

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<著者名表記>TATSUMI-MIYAJIMA, JunkoIt has been reported in epidemiological studies that prenatal exposure to chemicals such as polychlorinated biphenyl, valproic acid and nicotine during pregnancy increases the risk of developmental disabilities in childhood. In this study, we examined neurobehavioral characteristics in offspring naturally delivered from dams treated with cytosine arabinoside (cytosine-β-D-arabino furanoside ; Ara-C) to elucidate the association between the prenatal exposure to chemicals and the behavioral disorder. In the open field test, Ara-C prenatally exposed offspring showed a higher activity than control mice （p<0.05）. The inhibitory avoidance response in elevated T-maze test and the freezing response in elevated plat-form test was significantly increased in the Ara-C exposed mice compared to the control mice（p<0.05 or p<0.01）. On the other hand, the memory performance in passive avoidance test did not significantly differ between control and Ara-C exposed groups. The concentration of dopamine and serotonin in the brain was significantly increased in Ara-C exposed compared mice to the control mice（ｐ<0.05 or ｐ<0.01）. These findings suggest that the prenatal exposure to Ara-C induces behavioral disorder such as increased anxiety to be reflected by the quantitative changes of serotonin and dopamine in the brain of offspring.
近畿大学理工学部の論文