Long-term effects of post-ischemic estrogen on brain injury in a rat transient forebrain ischemia model
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Background: Post-treatment with estrogen reduced ischemic cerebral injury in some investigations, in which brain injury was evaluated only after a short recovery period. The current study was conducted to compare the effects of post-treatment with estrogen on histological and neurological outcomes after short (7-day) and long (28-day) recovery periods in rats subjected to transient forebrain ischemia. Methods: Male Sprague-Dawley rats were randomly assigned to one of five groups: vehicle (7-day recovery period), vehicle (28-day recovery period), estrogen (17β-estradiol 200 μg/kg, 7-day), estrogen (17β-estradiol 200 μg /kg, 28-day), or sham surgical (n=8 in each group). After forebrain ischemia was induced with bilateral carotid artery occlusion and hemorrhagic hypotension (mean arterial pressure = 40 mmHg) for 10 minutes, the brain was reperfused for 7 days or 28 days. Either 17β-estradiol or vehicle was injected intravenously during the initial 2 minutes of reperfusion. To evaluate histological damage, the number of intact neurons per 1 mm in the hippocampal CA1 subfield was counted at 7 days or 28 days after transient forebrain ischemia. Results: At 7 days after ischemia, the number of intact neurons in the hippocampal CA1 subfield was significantly greater in the estrogen group (57±37/mm: mean±SD) than in the vehicle group (15±15/mm; P=0.01). However, there was no difference between groups at 28 days after ischemia (vehicle: 13±11/mm vs. estrogen: 12±12/mm). Conclusion: The current study indicates that post-ischemic administration of estrogen provided short-term but not long-term neuroprotective effects in transient forebrain ischemia in rats.
- John Wiley & Sons Ltdの論文
John Wiley & Sons Ltd | 論文
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