抗ウイルス鶏卵抗体（IgY）による受動免疫効果に関する研究-I : コイにおける抗コイヘルペスウイルスIgYの受動免疫効果

概要

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Koi herpesvirus（KHV）disease causes mass mortalities in the world, however there is no ways to treat this disease. We tried passive immunization by intramuscular injections with anti KHV-IgY （Immunoglobulin Yolk＝Egg yolk antibody）in order to protect koi from KHV infection. Injected IgY containing anti KHV-IgY was absorbed into the blood serum at high concentration in day 1 after three injections, which was maintained to day 14. The immunized fish were challenged by immersion with cultured KHV in day 1 and were protected from KHV infection at 95％ RPS. The results indicate that passive immunization using anti KHV-Ig Y is effective to protect koi from KHV.
三重大学大学院生物資源学研究科の論文