Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1
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概要
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Diabetes mellitus is a global disease, and the number of patients with it is increasing. Of various agentsfor treatment, those that directly act on muscle are currently attracting attention because muscle is oneof the main tissues in the human body, and its metabolism is decreased in type II diabetes. In this study,we found that hydroxylamine (HA) enhances glucose uptake in C2C12 myotubes. Analysis of HA'smechanism revealed the involvement of IRS1, PI3 K and Akt that is related to the insulin signalingpathway. Further investigation about the activation mechanism of insulin receptor or IRS1 by HA mayprovide a way to develop a novel anti-diabetic agent alternating to insulin.
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Elsevier | 論文
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