Decrease in Skin Permeation and Antibacterial Effect of Parabens by a Polymeric Additive, Poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate)
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory effect of poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate) (PMB) on the in vitro skin permeation of p-hydroxybenzoic acid and its esters (parabens; methylparaben, ethylparaben, n-propylparaben and n-butylparaben) as model compounds was evaluated. Solubility of the parabens in distilled water was increased by addition of PMB, and the increasing ratio was dependent on the concentration of PMB. The increment of the ratio was more marked in lipophilic parabens than hydrophilic ones. Skin permeability of parabens from their aqueous suspensions was decreased by addition of PMB, and the decreasing ratio was dependent on the PMB concentration. Then, antibacterial effect of parabens of their aqueous solutions was determined with and without PMB by measuring minimum inhibitory concentration (MIC) against E. coli and S. aureus. As results, MIC and antibacterial effect were increased and decreased, respectively, by addition of PMB. The contribution of PMB was more marked in butylparaben than methylparaben. These decreases in skin permeation and antibacterial effect of parabens by PMB are probably due to a higher solubility in water and a lower partition to the skin and bacterial membranes of parabens by addition of PMB.
- 日本薬学会の論文
日本薬学会 | 論文
- Rapid and Sensitive Detection of Lophophora williamsii by Loop-Mediated Isothermal Amplification
- マウス摘出下部消化管におけるバニロイド受容体TRPV1の局在とカプサイシン誘起平滑筋収縮作用機序の解明 (生体機能と創薬シンポジウム2008--生命システムにおける情報ネットワークの重要性を解く 講演要旨集)
- NOを介する附子アルカロイド・メサコニチンの内皮依存性血管弛緩作用 (生体機能と創薬シンポジウム2007--創薬研究のルネサンスをめざして 講演要旨集) -- (シンポジウム 気体メディエーターと創薬)
- リンゴ未熟果由来プロアントシアニジンの食物アレルギー感作誘導抑制作用に関する研究 (第15回天然薬物の開発と応用シンポジウム講演要旨集) -- (一般講演)
- 新たな創薬ターゲットとしての膵β細胞機能調節因子 (生体機能と創薬シンポジウム2007--創薬研究のルネサンスをめざして 講演要旨集) -- (シンポジウム メタボリックシンドロームを巡る創薬)