Diastereoselective Synthesis of 3-Fluoro-2-substituted Piperidines and Pyrrolidines
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概要
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A facile procedure for synthesis of trans-3-fluoro-2-substituted piperidines by utilizing electrophilic fluorination of cyclic enamines and Lewis acid mediated nucleophilic substitution has been developed. Also, optically active trans-2-allyl-3-fluorinated pyrrolidines have been prepared by utilizing nucleophilic fluorination of hydroxyl group of trans-hydroxy-L-proline and Lewis acid mediated diastereoselective allylation as key steps.
- 日本複素環化学研究所の論文
日本複素環化学研究所 | 論文
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