Assessment of the physical properties and stability of mixtures of tetracycline hydrochloride ointment and acyclovir cream

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In dermatology, ointments are often mixed as part of drug therapy, but mixing often leads to incompatibility. Three combinations of tetracycline ointment (TC-o) and acyclovir cream (ACV-cr) were prepared at a TC-o:ACV-cr ratio of 1:1 using a brand-name ACV-cr and two generic ACV-cr (samples TC-o + ACV-A, TC-o + ACV-B, and TC-o + ACV-C). Microscopic examination revealed separation in TC-o + ACV-C. Viscosity and elasticity measurement indicated that the storage modulus (G′) and loss modulus (G″) of each of the TC-o + ACV-cr mixtures behaved similarly to those of an ACV-cr and the loss tangent (tan δ) behaved similarly to that of a TC ointment. In addition, differences in the storage modulus (G′) and loss modulus (G″) of the TC-o + ACV-cr mixtures were noted. To assess stability, each TC-o + ACV-cr mixture was stored away from direct sunlight at 25 °C and an RH of 84% and at 4 °C (in a refrigerator). HPLC revealed that the ACV content in each TC-o + ACV-cr mixture remained at 95?105% for up to 14 days under both sets of storage conditions. A decline in TC content in each TC-o + ACV-cr mixture was not noted with storage at 4 °C but was noted over time with storage at 25 °C and an RH of 84%. In addition, significant differences in the percent decline in TC content in each TC-o + ACV-cr mixture occurred with storage at 25 °C and an RH of 84%. Thus, differences in physical properties and stability may occur when combining brand-name and generic drugs, and temperature and humidity may be the cause of the TC-o's incompatibility.
Elsevierの論文

著者

古屋香代子
城西大学薬学部

Assessment of the physical properties and stability of mixtures of tetracycline hydrochloride ointment and acyclovir cream

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