Glycine cleavage system in neurogenic regions
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概要
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The glycine cleavage system (GCS) is the essential enzyme complex fordegrading glycine and supplying 5,10-methylenetetrahydrofolate for DNAsynthesis. Inherited deficiency of this system causes non-ketotichyperglycinemia, characterized by severe neurological symptoms andfrequent association of brain malformations. Although high levels ofglycine have been considered to cause the above-mentioned problems, thedetailed pathogenesis of this disease is still unknown. Here we show thatGCS is abundantly expressed in rat embryonic neural stem/progenitorcells in the neuroepithelium, and this expression is transmitted to theradial glia-astrocyte lineage, with prominence in postnatal neurogenicregions. These data indicate that GCS plays important roles inneurogenesis, and suggest that disturbance of neurogenesis induced bydeficiency of GCS may be the main pathogenesis of non-ketotichyperglycinemia
- Blackwell Publishingの論文
- 2004-03-00
Blackwell Publishing | 論文
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