Diethyl Phthalate Enhances Apoptosis Induced by Serum Deprivation in PC12 Cells
スポンサーリンク
概要
- 論文の詳細を見る
In this study, to examine the mechanism of diethyl phthalate toxicity to cells, the effects of diethyl phthalate on apoptosis in a PC12 cell system were investigated by assaying apoptotic factors such as caspase-3, Bax, cytochrome c and DNA damage.Diethyl phthalate was shown to enhance the apoptosis induced by serum deprivation according to the results of DNA electrophoresis and TUNEL signal assays, although it could not induce apoptosis itself in the cells. This enhancement was thought to be because of an increase in caspase-3-like activity. In addition, the expression of bax and contents of cytochrome cin the cytosol showed a tendency to increase the cells exposed to diethyl phthalate. These results indicated that diethyl phthalate, a potential endocrine disrupter, affects the apoptotic system in PC12 cells. Diethyl phthalate may enhance oxidative stress suchas that induced by reactive oxygen species in PC12 cells.
- Wiley-Blackwellの論文
- 2012-08-00
Wiley-Blackwell | 論文
- Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression
- Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma
- Running Test of VVVF Inverter Type Railcar Using Lithium Ion Battery
- Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells
- Palmitoylation of the sphingosine 1-phosphate receptor S1P1 is involved in its signaling functions and internalization