Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes
スポンサーリンク
概要
- 論文の詳細を見る
Numerous microbes inhabit the human intestine, many of which are uncharacterized or uncultivable. They form a complex microbial community that deeply affects human physiology. To identify the genomic features common to all human gut microbiomes as well as those variable among them, we performed a large-scale comparative metagenomic analysis of fecal samples from 13 healthy individuals of various ages, including unweaned infants. We found that, while the gut microbiota from unweaned infants were simple and showed a high inter-individual variation in taxonomic and gene composition, those from adults and weaned children were more complex but showed a high functional uniformity regardless of age or sex. In searching for the genes over-represented in gut microbiomes, we identified 237 gene families commonly enriched in adult-type and 136 families in infant-type microbiomes, with a small overlap. An analysis of their predicted functions revealed various strategies employed by each type of microbiota to adapt to its intestinal environment, suggesting that these gene sets encode the core functions of adult and infant-type gut microbiota. By analysing the orphan genes, 647 new gene families were identified to be exclusively present in human intestinal microbiomes. In addition, we discovered a conjugative transposon family explosively amplified in human gut microbiomes, which strongly suggests that the intestine is a 'hot spot' for horizontal gene transfer between microbes.
- Oxford University Pressの論文
- 2007-08-00
著者
関連論文
- 5.ゲノムデータの視覚化による効果的な理解(バイオデータベースの今)
- 高レベル放射性廃棄物処分に関するシミュレーション
- HGREP (Human Genome REconstruction Project) の使い方
- Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes